![]() Progressive amplification of the response of an organism from the repeated intermittent exposure to the same or a cross-sensitizing stressor or agent (drug, chemical, biological factor) at physiological limits, TDS can oscillate in biphasic directions. 3, 4Īdverse physiological consequences of long-term exposure to repeated or chronic stress, leading to disease involves nonlinear interactions of central and autonomic nervous systems, neuroendocrine, immune, and metabolic networks of the organism. Physiological adaptive process of achieving or restoring homeostasis through physiological and/or behavioral change involving positive and/or negative feedback. Physiological phenomenon in which exposure to a given adverse environment leads to an increase in tolerance not only for the original environment, but also to changes in tolerance to other adverse factors that the adapted organism had never previously encountered. A form of biological learning or plasticity. 27, 38– 39, 51, 55– 57Įvolutionary process affecting structure, behavior, and/or physiology in which an organism changes to survive and thrive over time within a given environment. 3, 4Ī biphasic dose response relationship involving low dose stimulation (beneficial compensatory changes) and high dose inhibition (toxicity) an adaptive response of cells and organisms to a moderate intermittent stress. ![]() 25, 115Īny environmental or endogenous change that serves to perturb physiological or cellular homeostasis in an organism, i.e., the stable internal state of functioning necessary for maintenance of life. NPs adsorb proteins, DNA, and other substances onto their surfaces cross membranes easily act as highly reactive and catalytic agents that lower the amount of drug or herb needed to produce a given effect. 1, 13, 24 Nanoparticles (NPs) have different properties from their bulk forms in terms of mechanical, optical, electrical, magnetic, chemical, biological, and quantum behaviors. The central proposition is that homeopathic treatment is a form of nanomedicine acting by modulation of endogenous adaptation and metaplastic amplification processes in the organism to enhance long-term systemic resilience and health.Ī small particle with one or more dimensions measuring 100 nanometers or less. The NPCAS model suggests a way forward for systematic research on homeopathy. Simillimum remedy nanoparticles, as novel mild stressors corresponding to the organism’s dysfunction initiate time-dependent cross-sensitization, reversing the direction of dysfunctional reactivity to environmental stressors. Homeopathic remedies modulate adaptive allostatic responses, with multiple dynamic short- and long-term effects. This paper examines research implications of the model, discussing the following hypotheses: Variability in nanoparticle size, morphology, and aggregation affects remedy properties and reproducibility of findings. ![]() Evidence for nanoparticle-related quantum macro-entanglement in homeopathic pathogenetic trials. ![]() Clinical matching of the patient’s symptom picture, including modalities, to the symptom pattern that the source material can cause (cross-adaptation and cross-sensitization). Hormetic adaptive responses in the organism, triggered by nanoparticles bipolar, metaplastic change, dependent on the history of the organism. The model accommodates the requirement for measurable physical agents in the remedy (source nanoparticles and/or source adsorbed to silica nanoparticles). Key concepts of the Nanoparticle-Allostatic Cross-Adaptation-Sensitization (NPCAS) Model for the action of homeopathic remedies in living systems include source nanoparticles as low level environmental stressors, heterotypic hormesis, cross-adaptation, allostasis (stress response network), time-dependent sensitization with endogenous amplification and bidirectional change, and self-organizing complex adaptive systems.
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